卵巢癌
肿瘤微环境
离体
转移
脂肪组织
癌症研究
免疫系统
癌症
恶性肿瘤
癌细胞
体内
医学
生物
免疫学
病理
内科学
生物技术
作者
Terrence N. Wong,Roslyn Tedja,Hussein Chehade,Robert T. Morris,Ayesha B. Alvero,Gil Mor
摘要
Ovarian cancer is the deadliest gynecologic malignancy. The omentum plays a key role in providing a supportive microenvironment to metastatic ovarian cancer cells as well as immune modulatory signals that allow tumor tolerance. However, we have limited models that closely mimic the interaction between ovarian cancer cells and adipose-rich tissues. To further understand the cellular and molecular mechanisms by which the omentum provides a pro-tumoral microenvironment, we developed a unique 3D ex vivo model of cancer cell-omentum interaction. Using human omentum, we are able to grow ovarian cancer cells within this adipose-rich microenvironment and monitor the factors responsible for tumor growth and immune regulation. In addition to providing a platform for the study of this adipose-rich tumor microenvironment, the model provides an excellent platform for the development and evaluation of novel therapeutic approaches to target metastatic cancer cells in this niche. The proposed model is easy to generate, inexpensive, and applicable to translational investigations.
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