透明质酸
多西紫杉醇
壳聚糖
结直肠癌
纳米颗粒
核化学
化学
化学工程
材料科学
医学
化疗
内科学
纳米技术
有机化学
癌症
工程类
解剖
作者
Sobia Noreen,Fahad Pervaiz,Muhammad Ijaz,Muhammad Hanif,Jam Riyan Hamza,Hassan Mahmood,Hina Shoukat,Irsah Maqbool,Majid Ashraf
出处
期刊:Nanomedicine
日期:2024-02-09
标识
DOI:10.2217/nnm-2023-0318
摘要
Aim: This study aimed to develop and evaluate pH-sensitive docetaxel-loaded thiolated hyaluronic acid (HA-SH) nanoparticles (NPs) for targeted treatment of colon cancer. Materials & methods: HA-SH, synthesized via oxidation and subsequent covalent linkage to cysteamine, served as the precursor for developing HA-SH NPs through polyelectrolyte complexation involving chitosan and thiol-bearing HA. Results & conclusion: HA-SH NPs displayed favorable characteristics, with small particle sizes (184–270 nm), positive zeta potential (15.4–18.6 mV) and high entrapment efficiency (91.66–95.02%). In vitro, NPs demonstrated potent mucoadhesion and enhanced cytotoxicity compared with free docetaxel. In vivo assessments confirmed safety and biocompatibility, suggesting HA-SH NPs as promising pH-sensitive drug carriers with enhanced antitumor activity for colorectal cancer treatments.
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