嵌合抗原受体
不良事件报告系统
不利影响
医学
细胞因子释放综合征
数据库
优势比
内科学
肿瘤科
免疫疗法
癌症
计算机科学
作者
Na Zhao,Fangyuan Hu,Yinghong Zhai,Ye Xia,Yijun Ruan,Zhen Liu,Zhiyan Wang,Wenbin Shen,Lei Yuan
出处
期刊:Immunotherapy
[Future Medicine]
日期:2024-02-01
卷期号:16 (3): 161-172
标识
DOI:10.2217/imt-2023-0220
摘要
Aim: The purpose of this study was to comprehensively explore the ocular toxicity associated with chimeric antigen receptor (CAR) T-cell therapy. Materials & methods: Data were assembled from the US FDA's Adverse Event Reporting System (FAERS) database from 2017 to 2023. Information component and reporting odds ratio methods were used for signal detection in total/categorized CAR T-cell therapy. Results: A total of 17 positive signals (preferred term) were detected, yet none of them were documented in the product information. Some adverse events were with death outcomes and overlapped a lot with cytokine-release syndrome. Conclusion: The ocular adverse events associated with CAR-T cell therapy are noteworthy, and it is imperative to maintain increased alertness and institute early intervention strategies.
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