化学
石墨烯
氧化物
聚合物
间质液
航程(航空)
纳米技术
化学工程
高分子化学
有机化学
材料科学
复合材料
内科学
医学
工程类
作者
Md Selim Reza,Sookyeong Seonu,Md Abu Zahed,Md Asaduzzaman,Hyesu Song,Seong Hoon Jeong,Jae Yeong Park
出处
期刊:Talanta
[Elsevier]
日期:2024-04-01
卷期号:270: 125582-125582
标识
DOI:10.1016/j.talanta.2023.125582
摘要
Despite substantial developments in minimally invasive lactate monitoring microneedle electrodes, most such electrode developments have focused on either sensitivity or invasiveness while ignoring a wide range of detection, which is the most important factor in measuring the normal range of lactate in interstitial fluid (ISF). Herein, we present a polymer-based planar microneedle electrode fabrication using microelectromechanical and femtosecond laser technology for the continuous monitoring of lactate in ISF. The microneedle is functionalized with two-dimensional reduced graphene oxide (rGO) and electrochemically synthesized platinum nanoparticles (PtNPs). A particular quantity of Nafion (1.25 wt%) is applied on top of the lactate enzyme to create a diffusion-controlled membrane. Due to the combined effects of the planar structure of the microneedle, rGO, and membrane, the biosensor exhibited excellent linearity up to 10 mM lactate with a limit of detection of 2.04 μM, high sensitivity of 43.96 μA mM−1 cm−2, a reaction time of 8 s and outstanding stability, selectivity, and repeatability. The feasibility of the microneedle is evaluated by using it to measure lactate concentrations in artificial ISF and human serum. The results demonstrate that the microneedle described here has great potential for use in real-time lactate monitoring for use in sports medicine and treatment.
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