环丙烷化
环丙烷
化学
全合成
组合化学
试剂
立体化学
立体专一性
有机化学
催化作用
戒指(化学)
作者
Ramsha Munir,Ameer Fawad Zahoor,Sadia Javed,Bushra Parveen,Asim Mansha,Ahmad Irfan,Samreen Gul Khan,Ali Irfan,Katarzyna Kotwica-Mojzych,Mariusz Mojzych
出处
期刊:Molecules
[MDPI AG]
日期:2023-07-26
卷期号:28 (15): 5651-5651
标识
DOI:10.3390/molecules28155651
摘要
Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be realized by the fact that the cyclopropane motif is a privileged synthetic intermediate and a core structural unit of many biologically active natural compounds such as terpenoids, alkaloids, nucleosides, amino acids, fatty acids, polyketides and drugs. The modified form of Simmons–Smith cyclopropanation involves the employment of Et2Zn and CH2I2 (Furukawa reagent) toward the total synthesis of a variety of structurally complex natural products that possess broad range of biological activities including anticancer, antimicrobial and antiviral activities. This review aims to provide an intriguing glimpse of the Furukawa-modified Simmons–Smith cyclopropanation, within the year range of 2005 to 2022.
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