油胺
纳米技术
纳米材料
纳米颗粒
超顺磁性
材料科学
表面改性
氧化铁纳米粒子
分子
化学工程
化学
有机化学
物理
磁化
量子力学
磁场
工程类
作者
Niki Karouta,Yannis V. Simos,Georgia Basina,Konstantinos Spyrou,Mohammed Subrati,Alexandra V. Chatzikonstantinou,Mohamed Amen Hammami,Vasileios Tzitzios,Saeed M. Alhassan,Yasser Al Wahedi,Alexios P. Douvalis,G. C. Hadjipanayis,Konstantinos I. Tsamis,Evangelia Dounousi,Γεώργιος Μαρκόπουλος,Sofia Bellou,Vasilios Georgakilas,Dimitrios Peschos,Zili Sideratou,Haralambos Stamatis,Dimitrios Gournis,Emmanuel P. Giannelis
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2023-02-15
卷期号:6 (4): 2770-2783
被引量:3
标识
DOI:10.1021/acsanm.2c04006
摘要
Superparamagnetic iron oxide nanoparticles (SPIONs) are becoming important vehicles for biomedical applications. This study demonstrates a new strategy based on a “haircut” reaction, aiming at the design of highly hydrophilic and functional nanoparticles. The as-synthesized SPIONs have a diameter of ∼4 nm and reveal super-organophilic behavior due to their surface modification by oleylamine molecules present on their surface (o-SPIONs). The “trimming”, which is applied on the oleylamine molecule double bond, produces shorter chains terminated by carboxyl groups, with the resulting nanoparticles exhibiting high hydrophilicity, dispersibility in water, and functionality (h-SPIONs). The biological behavior of h-SPIONs is studied against three different cell lines and reveals a selective cytotoxic effect against cancer cells. This novel method of engineering the surface properties of nanoparticles can lead to the development of a new generation of functional nanomaterials. In addition, h-SPIONs can evolve into a new and expanding family of magnetic nanomaterials in future biomedical systems.
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