The Role of Photobiomodulation Therapy in Reducing Stress-Induced Changes in the Hippocampus of Rats during Septoplasty Modeling

The aim of the study was to investigate the effect of photobiomodulation therapy (PBMT) on the amount of p53 in neurons of the pyramidal layer of the hippocampus after modeling septoplasty in rats. MATERIALS AND METHODS: Septoplasty was modeled in 48 Wistar rats. PBMT was administered to 24 rats in the early postoperative period for 2 to 6 days. Histological sections of the hippocampus were studied to determine p53-positive neurons on days 2, 4, and 6 after surgery in rats of both groups. RESULTS: Compared with the control group (n = 5 rats), in both experimental groups there was an increase in the number of p53-positive neurons in the hippocampus, however, in the group where PBMT was performed in the early postoperative period after modeling septoplasty, the number of such neurons was lower, and in some subfields of the hippocampus on day 6 it even corresponded to the control group. CONCLUSIONS: The use of PBMT in the early postoperative period after modeling septoplasty helps to reduce stress-induced expression of the p53 protein in the pyramidal layer of the hippocampus in rats.