Polyprenylated acylphloroglucinols from Hypericum attenuatum and their antidepressant activities

Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (1-3), were ioslated from the 90% EtOH extract of the air dried aerial parts of Hypericum attenuatum. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy. All the isolated compounds were evaluated for their antidepressant activity by inhibiting reuptake of tritiated serotonin ([³H]-5-HT) and noradrenalinet ([³H]-NE) in rat brain synaptosomes. Compounds 2 exhibited some antidepressant activities in the [³H]-5-HT mode.