Bioactive Self‐Pumping Janus Fibrous Hydrogel Dressings with Aligned Microneedle Channels for Chronic Wound Healing

Abstract Chronic wounds frequently lead to infections and complicated treatments, causing edema, pain, suppuration, and delayed healing, increasing the risk of limb loss. Conventional wound dressings struggle with biofluid drainage, prolonging inflammation and impairing tissue regeneration. This study presents a tri‐layer self‐pumping Janus fibrous hydrogel scaffold (SPFH) designed to drain exudates while promoting chronic wound healing. The inner‐thin hydrophobic layer comprises thermoplastic polyurethane nanofibers known as the drainage layer, which prevents exudate accumulation and secondary complications. The mid‐hydrogel layer with aligned microneedle channels comprises dopamine‐modified platelet lysate‐methacrylate reinforced with core/shell silver‐modified mesoporous silica nanoparticles form the supramolecular network, performs hemostatic, antibacterial, anti‐inflammatory, angiogenic, and self‐pumping functions. The microneedle channels and capillary action between the drainage and hydrogel layer transport the exudate from the wound site to the outer layer, which comprises dopamine‐modified cellulose acetate and serves as an antifouling storage layer. In vivo experiments validated the SPFH effectiveness in reducing wound exudate and inflammation, stimulating angiogenesis, and accelerating chronic wound healing due to its unique asymmetric wettability and direct wound contact of bioactive microneedle channels. Overall, the biocompatible SPFH demonstrates remarkable mechanical, antibacterial, anti‐inflammatory, cell migration/proliferation, angiogenic, and self‐pumping capabilities, highlighting its potential as a novel biomaterial for chronic wound management.