化学
芳基
激进的
烯烃纤维
镍
催化作用
三氟甲基
药物化学
立体化学
赫克反应
组合化学
钯
有机化学
烷基
作者
Jian Liu,Yeonchul Hong,Yin-Ling Liu,Jieqing Tan,Haomiao Liu,Gang-Liang Dai,Shi‐Lu Chen,Ting Liu,Jin‐Heng Li,Shi Tang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-01
卷期号:24 (44): 8192-8196
被引量:3
标识
DOI:10.1021/acs.orglett.2c03250
摘要
A bromoalkane-directed radical 1,4-aryl shift strategy for nickel-catalyzed reductive Heck-type C(sp3)-C(sp2) coupling cascades of α-amino-β-bromocarboxylic acid esters with α-trifluoromethyl alkenes for producing gem-difluorinated arylalanines is presented. The α-aminoalkyl radicals generated from neophyl-type aryl migration function as robust coupling partners to allow for further Giese-type addition with electron-deficient α-trifluoromethyl alkenes and vinyl sulfones, thereby realizing a new radical cascade for the simultaneous installation of an aromatic ring and olefin motif into amino acid backbones.
科研通智能强力驱动
Strongly Powered by AbleSci AI