材料科学
生物相容性
钙
抗氧化剂
肾结石
草酸钙
细胞毒性
体内
肾
草酸盐
结晶
氧化应激
冶金
体外
无机化学
医学
生物化学
内科学
生物
化学
有机化学
生物技术
作者
Bo Yang,Mei Shan Zhao,Jingcheng Lv,Xiao Chuan Wang,You Quan Zhao,Jun Li,Fang Zhao
标识
DOI:10.1016/j.ceramint.2022.11.063
摘要
The prevalence of kidney stones continues to increase worldwide, however, there are still short of effective drugs against urinary stones. In our study, we developed and utilized porous [email protected]2 nanospheres as the novel antioxidant agent to detect its potential effects on crystallization inhibition. Porous [email protected]2 nanospheres enable to deliver Se sustainably with lower cytotoxicity and preferred biocompatibility. In vivo, we found that porous [email protected]2 nanospheres markedly decreased CaOX crystal deposition in renal parenchyma and alleviated kidney oxidative damage. In vitro, we found that the antioxidant effects of porous [email protected]2 nanospheres were mediated by upregulation of HO-1 and activation of Keap1/Nrf2 pathway. These results suggests that porous [email protected]2 nanospheres may be a new promising therapeutic option for stone formers.
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