化学
钯
电泳剂
亲核细胞
催化作用
芳基
取代基
试剂
碘化物
偶联反应
药物化学
羟胺
有机化学
组合化学
烷基
作者
Zhicheng Bao,Chao Wu,Jianbo Wang
标识
DOI:10.1002/ejoc.202201264
摘要
Abstract We report herein the application of 1,1‐bis[(pinacolato)boryl]methane as a new type of terminating reagent to realize three‐component coupling reaction with aryl iodide and different electrophiles. A series of ortho‐disubstituted benzylboronates can be synthesized and the ortho‐substituent can be varied by using bromoacetic esters or O‐benzoyl hydroxylamine as electrophiles with slightly modified reaction conditions. The reaction shows good functional group tolerance and the obtained benzyl boronate products can be easily transformed to various synthetically useful compounds.
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