Trajectories of pain and their associations with long-term cognitive decline in older adults: evidence from two longitudinal cohorts

认知功能衰退 认知 医学 限制 纵向研究 心理干预 物理疗法 物理医学与康复 老年学 痴呆 内科学 精神科 机械工程 工程类 病理 疾病
作者
Zijun He,Gege Li,Zhi Chen,Zihang Hu,Qing-Wei Wang,Guozhi Huang,Qinglu Luo
出处
期刊:Age and Ageing [Oxford University Press]
卷期号:53 (8) 被引量:1
标识
DOI:10.1093/ageing/afae183
摘要

Abstract Background Pain is a dynamic experience that varies over time, but it remains unknown whether trajectories of pain are associated with subsequent cognitive decline. The purpose of this study was to identify distinct trajectories of pain presence and activity-limiting pain and investigate their longitudinal associations with the rate of subsequent cognitive decline in older adults. Methods A total of 5685 participants from the English Longitudinal Study of Ageing (ELSA) and 7619 participants from the Health and Retirement Study (HRS) were included. Pain presence trajectories were identified over eight years in the ELSA and 10 years in the HRS, while trajectories of activity-limiting pain were identified over 10 years in the HRS. We utilised linear mixed-effects models to investigate the long-term relationship between pain trajectories and the rate of cognitive decline across various domains, including memory, orientation, executive function and global cognition. Results Three pain presence trajectories were identified. Moderate-increasing and high-stable groups exhibited steeper declines in global cognition than the low-stable group. Furthermore, individuals in the moderate-increasing group experienced a more rapid decline in executive function, while the high-stable group showed a faster decline in orientation function. Two trajectories of activity-limiting pain were identified, with the moderate-increasing group experiencing a faster decline in orientation function and global cognition. Conclusions The trajectories of both pain presence and activity-limiting pain are linked to the rate of subsequent cognitive decline among older people. Interventions for specific pain trajectories might help to delay the decline rate of cognition in specific domains.
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