多巴胺
多金属氧酸盐
生物标志物
环糊精
超分子化学
化学
电化学气体传感器
纳米技术
电化学
组合化学
材料科学
神经科学
色谱法
心理学
生物化学
电极
催化作用
有机化学
物理化学
晶体结构
作者
Saptami Suresh Shetty,Basem Moosa,Li Zhang,Buthainah Alshankiti,Walaa Baslyman,Veerappan Mani,Niveen M. Khashab,Khaled N. Salama
标识
DOI:10.1016/j.bios.2023.115240
摘要
Optimized and sensitive biomarker detection has recently been shown to have a critical impact on quality of diagnosis and medical care options. In this research study, polyoxometalate-γ-cyclodextrin metal-organic framework (POM-γCD MOF) was utilized as an electrocatalyst to fabricate highly selective sensors to detect in-situ released dopamine. The POM-γCD MOF produced multiple modes of signals for dopamine including electrochemical, colorimetric, and smartphone read-outs. Real-time quantitative monitoring of SH-SY5Y neuroblastoma cellular dopamine production was successfully demonstrated under various stimuli at different time intervals. The POM-CD MOF sensor and linear regression model were used to develop a smartphone read-out platform, which converts dopamine visual signals to digital signals within a few seconds. Ultimately, POM-γCD MOFs can play a significant role in the diagnosis and treatment of various diseases that involve dopamine as a significant biomarker.
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