脚手架
PLGA公司
材料科学
生物医学工程
再生(生物学)
牙槽
形状记忆合金
聚合物
多孔性
复合材料
牙科
纳米技术
医学
纳米颗粒
细胞生物学
生物
作者
Wei Zhang,Meilin Yu,Yongqiang Cao,Zihan Zhuang,Kunxi Zhang,Dong Chen,Wenguang Liu,Jingbo Yin
标识
DOI:10.1016/j.bioactmat.2022.08.030
摘要
The regeneration of alveolar bone after tooth extraction is critical for the placement of dental implants. Developing a rigid porous scaffold with defect shape adaptability is of great importance but challenging for alveolar bone regeneration. Herein, we design and synthesize a biocompatible poly( l -glutamic acid)- g -poly( ε -caprolactone) (PLGA- g -PCL) porous shape memory (SM) polymer. The PLGA- g -PCL is then copolymerized with acryloyl chloride grafted poly( ω -pentadecalactone) (PPDLDA) having a higher phase transition temperature than shape recovery temperature to maintain stiffness after shape recovery to resist chewing force. The hybrid polydopamine/silver/hydroxyapatite (PDA/Ag/HA) is coated to the surface of (PLGA- g -PCL)-PPDL scaffold to afford the anti-bacterial activity. The porous SM scaffold can be deformed into a compact size and administered into the socket cavity in a minimally invasive mode, and recover its original shape with a high stiffness at body temperature, fitting well in the socket defect. The SM scaffold exhibits robust antibacterial activity against Staphylococcus aureus ( S. aureus ). The porous microstructure and cytocompatibility of PLGA allow for the ingrowth and proliferation of stem cells, thus facilitating osteogenic differentiation. The micro-CT and histological analyses demonstrate that the scaffold boosts efficient new bone regeneration in the socket of rabbit mandibular first premolar. This porous shape memory self-adaptive stiffened polymer opens up a new avenue for alveolar bone regeneration. An anti-bacterial porous shape memory self-adaptive stiffened polymer scaffold fabricated from copolymerization of biocompatible poly( l -glutamic acid)- g -poly(ε-caprolactone) (PLGA- g -PCL) with purposely selected acryloyl chloride-poly(ω-pentadecalactone) (PPDLDA) having a higher phase transition temperature than shape recovery temperature can be deformed into a compact size, fit well in rabbits’ socket cavity, and recover original shape with a high stiffness in vivo , boosting alveolar bone regeneration. • A self-adaptive, stiffened, porous shape memory scaffold with anti-bacterial activity is applied for alveolar bone regeneration. • Polymer with higher transition temperature as rigid structure enhances mechanical strength of shape memory scaffold. • Excellent shape memory properties endow the scaffold with the satisfied self-adaptive ability in the socket defect. • The porous scaffold with biodegradability, anti-bacteria, cytocompatibility lead to boost alveolar bone regeneration.
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