小胶质细胞
生物
细胞生物学
星形胶质细胞
炎症
免疫学
中枢神经系统
神经科学
作者
Liliana M. Sanmarco,Michael A. Wheeler,Cristina Gutiérrez-Vázquez,Carolina Manganeli Polonio,Mathias Linnerbauer,Felipe A. Pinho‐Ribeiro,Zhaorong Li,Federico Giovannoni,Katelyn V. Batterman,Giulia Scalisi,Stéphanie Zandee,Evelyn S. Heck,Moneera Alsuwailm,Douglas L. Rosene,Burkhard Becher,Isaac M. Chiu,Alexandre Prat,Francisco J. Quintana
出处
期刊:Nature
[Springer Nature]
日期:2021-01-06
卷期号:590 (7846): 473-479
被引量:174
标识
DOI:10.1038/s41586-020-03116-4
摘要
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known about the homeostatic anti-inflammatory activities of astrocytes and their regulation. Here, using high-throughput flow cytometry screening, single-cell RNA sequencing and CRISPR-Cas9-based cell-specific in vivo genetic perturbations in mice, we identify a subset of astrocytes that expresses the lysosomal protein LAMP12 and the death receptor ligand TRAIL3. LAMP1+TRAIL+ astrocytes limit inflammation in the CNS by inducing T cell apoptosis through TRAIL-DR5 signalling. In homeostatic conditions, the expression of TRAIL in astrocytes is driven by interferon-γ (IFNγ) produced by meningeal natural killer (NK) cells, in which IFNγ expression is modulated by the gut microbiome. TRAIL expression in astrocytes is repressed by molecules produced by T cells and microglia in the context of inflammation. Altogether, we show that LAMP1+TRAIL+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ+ NK cells that are licensed by the microbiome.
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