Research progress on the function of Lunatic Fringe in Notch signal pathway

The Notch signaling pathway is highly conserved, composed of Notch receptor, Notch ligand and other related protein molecules, and activated by three step protein lysis . LFNG (lunatic fringe), a key gene in the Notch signaling pathway, encodes a glycosyltransferase that recognizes and glycosylates the EGF (epithelial growth factor) repeat sequence on the Notch receptor, and is associated with the development of a variety of diseases such as bronchial asthma and cartilage dysplasia. In this paper, we review the functional studies on LFNG in recent years. Key words: Notch signaling pathway; LFNG; Tumor metabolism