医学
慢性阻塞性肺病
全身炎症
内科学
伯德指数
肺功能测试
体质指数
纤维蛋白原
胃肠病学
炎症
C反应蛋白
疾病
肿瘤坏死因子α
物理疗法
肺康复
作者
Onur Yazıcı,ST Gulen,Çiğdem Yenisey,Ufuk Eryılmaz,BI Abas,Mehmet Polatlı
出处
期刊:Nigerian Journal of Clinical Practice
日期:2020-01-01
卷期号:23 (6): 817-817
被引量:4
标识
DOI:10.4103/njcp.njcp_222_19
摘要
The Global Initiative classification (GOLD) for chronic obstructive pulmonary disease (COPD), which relies on the practical issues of treatment of this complex and heterogeneous disease, may not be reliable in predicting disease severity and prognosis as the term of inflammation is excluded from the definition.The aim of this study was to determine systemic inflammatory markers in GOLD ABCD groups and to compare these parameters according to clinical and functional features.The study included 60 COPD patients and 59 healthy subjects. Comparisons were made with the pulmonary function test, transthoracic echocardiography and the six-minute walk test (6MWT). The COPD assessment test (CAT), modified Medical Research Council (mMRC), and index scores of body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) were recorded. The systemic inflammatory state was assessed using C-reactive protein, fibrinogen, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-8 and IL-18.The levels of all serum inflammatory markers were higher in the COPD group than in the control group. TNF-α and IL-6 were significantly higher in the symptomatic groups (B and D) than in the less symptomatic groups (A and C) (P < 0.05). Spirometric parameters were more severe in Group D, followed by groups C, B and A, respectively. The 6MWT and the BODE scores were worst in Group D, followed by groups B, C and A.The results suggest that bronchodilator treatment alone might be insufficient in Group B patients, as the systemic inflammatory markers in addition to exercise capacity and mortality predictors were at the worst level in Groups D and B.
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