G蛋白偶联受体
受体
生物
免疫系统
神经科学
细胞生物学
细胞表面受体
跨膜蛋白
炎症
免疫受体
免疫学
生物化学
作者
Nadine Serhan,Nicolas Cénac,Lilian Basso,Nicolas Gaudenzio
标识
DOI:10.1016/j.neulet.2021.135724
摘要
Interplay between physiological systems in the body plays a prominent role in health and disease. At the cellular level, such interplay is orchestrated through the binding of specific ligands to their receptors expressed on cell surface. G protein-coupled receptors (GPCR) are seven-transmembrane domain receptors that initiate various cellular responses and regulate homeostasis. In this review, we focus on particular GPCRs named Mas-related G protein-coupled receptors (Mrgprs) mainly expressed by sensory neurons and specialized immune cells. We describe the different subfamilies of Mrgprs and their specific ligands, as well as recent advances in the field that illustrate the role played by these receptors in neuro-immune biological processes, including itch, pain and inflammation in diverse organs.
科研通智能强力驱动
Strongly Powered by AbleSci AI