促肾上腺皮质激素
免疫系统
皮质酮
下调和上调
医学
激素
内科学
内分泌学
麻醉
生物
免疫学
生物化学
基因
作者
Ying Tang,Yingxin Zou,Wei Fan,Shuanghong Chen,Yiqun Fang,Lina Liu,Ying Sun,Yong Giao
出处
期刊:Undersea & Hyperbaric Medicine
[Undersea and Hyperbaric Medical Society (UHMS)]
日期:2020-03-01
卷期号:47 (3): 445-453
被引量:2
标识
DOI:10.22462/03.07.2020.5
摘要
The present study was designed to assess the stress responses to a simulation model of the undersea environment that is similar to some undersea working conditions such as submarine rescue, underwater salvage and underwater construction. Restraint, hyperbaric air and immersion were chosen to produce the simulation stress model in rats for four hours. Rats were randomized into five groups: control group, restraint (R) group, hyperbaric air (H) group, restraint plus hyperbaric air (RH) group, and restraint plus hyperbaric air plus immersion (RHI) group. The results showed that the responses to the simulation stress model of the undersea environment induced by R, H, RH and RHI involved the upregulated norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) of the central nervous system (CNS), upregulated adrenocorticotropic hormone (ACTH), corticosterone (CORT) and blood glucose of the neuroendocrine system, upregulated interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) of the immune system, and increased anxiety in rats. Compared with hyperbaric air, restraint tended to activate stronger stress responses. Conclusively, this work established a simulation stress model of the undersea environment induced by restraint, hyperbaric air and immersion. It further provided experimental data of such a model that showed significant activation of the CNS, neuroendocrine and immune systems and anxiety in rats. In this experiment we provided an experimental basis for undersea work such as working aboard a submarine.
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