CD8型
细胞毒性T细胞
T细胞
免疫学
生物
免疫系统
人口
医学
内科学
生物化学
环境卫生
体外
作者
Lindsey E. Padgett,Huy Q. Dinh,Runpei Wu,Dalia E. Gaddis,Daniel J. Araujo,Holger Winkels,Anh Nguyen,Coleen A. McNamara,Catherine C. Hedrick
标识
DOI:10.1161/atvbaha.120.315106
摘要
Objective: Cardiovascular disease (CVD) remains a significant global health concern with a high degree of mortality. While CD4 + T cells have been extensively studied in CVD, the importance of CD8 + T cells in this disease, despite their abundance and increased activation in human atherosclerotic plaques, remains largely unknown. Thus, the objective of this study was to compare peripheral T-cell signatures between humans with a high (severe) risk of CVD (including myocardial infarction or stroke) and those with a low risk of CVD. Approach and Results: Using mass cytometry, we uncovered a naive CD8 + T (T N ) cell population expressing CD95 (termed CD95 + CD8 + stem cell memory T [CD8 T SCM ] cells) that was enriched in patients with high compared with low CVD. This T-cell subset enrichment within individuals with high CVD was a relative increase and resulted from the loss of CD95 lo cells within the T N compartment. We found that CD8 T SCM cells positively correlated with CVD risk in humans, while CD8 + T N cells were inversely correlated. Atherosclerotic apolipoprotein E-deficient (ApoE −/− ) mice also displayed respective 7- and 2-fold increases in CD8 + T SCM frequencies within the peripheral blood and aorta-draining paraaortic lymph nodes compared with C57BL/6J mice. CD8 + T SCM cells were 1.7-fold increased in aortas from western diet fed ApoE −/− mice compared with normal laboratory diet-fed ApoE −/− mice. Importantly, transfer of T SCM cells into immune-deficient Rag.Ldlr recipient mice that lacked T cells increased atherosclerosis, illustrating the importance of these cells in atherogenesis. Conclusions: CD8 + T SCM cells are increased in humans with high CVD. As these T SCM cells promote atherosclerosis, targeting them may attenuate atherosclerotic plaque progression.
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