医学
回顾性队列研究
内科学
优势比
败血症
肠外营养
置信区间
胃肠病学
风险因素
作者
Zhi Mao,Guoxiong Liu,Qing Yu,Shuang Qi,Yunchi Lou,Chao Liu,Qinglin Li,Chao Xue,Hongjun Kang,Quan Hong,Feihu Zhou
出处
期刊:Annals of Translational Medicine
[AME Publishing Company]
日期:2020-10-01
卷期号:8 (19): 1240-1240
被引量:9
摘要
To assess the association between serum lactate levels and intolerance to enteral nutrition (EN) in septic patients treated with vasopressors.This retrospective study was conducted between January 1, 2015 and May 1, 2018 in an intensive care unit (ICU). Patients with sepsis who were given EN and treated with vasopressors were included. EmpowerStats software and R (version 3.3.2) was used to examine the association between serum lactate levels and intolerance to EN.Among the 132 septic patients (age, 60.6±18.1 years) enrolled, 35 (26.5%) patients suffered intolerance to EN. Multiple logistic regression analysis demonstrated that an elevated lactate level was an independent risk factor for EN intolerance [odds ratio (OR): 2.7; 95% confidence interval (CI): 1.6-4.4; P<0.001]. The area under the receiver operating characteristic (ROC) curve for serum lactate levels was 0.764 (95% CI: 0.664-0.864). Stratified analysis suggested that age was the most prominent interactive factor for serum lactate levels in EN intolerance. Serum lactate levels were closely correlated to EN intolerance in elderly patients (age ≥65 years) (OR: 9.5; 95% CI: 2.1-42.4; P=0.0261 for interaction), while no such association was identified in younger patients (age <65 years; OR: 1.7; 95% CI: 1.0-2.9; P=0.052).Serum lactate levels were associated with an increased risk of EN intolerance in patients with sepsis, especially in elderly individuals. An elevated serum lactate level may be an early predictor of EN intolerance in elderly septic patients treated with vasopressors. However, further studies are called for to verify these findings.
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