材料科学
葡萄糖氧化酶
卟啉
纳米颗粒
胶体金
催化作用
纳米片
纳米技术
过氧化氢
光化学
拉曼光谱
化学工程
拉曼散射
生物传感器
无机化学
有机化学
光学
物理
工程类
化学
作者
Sen Hu,Yuning Jiang,Yiping Wu,Xiaoyu Guo,Ying Ye,Ying Wen,Haifeng Yang
标识
DOI:10.1021/acsami.0c12988
摘要
In this work, an S hybrid nanosheet with multiple functions is synthesized by in situ modification of gold nanoparticles (AuNPs) onto two-dimensional (2D) metalloporphyrinic metal–organic framework (MOF) (Cu-tetra(4-carboxyphenyl)porphyrin chloride(Fe(III)), designated as AuNPs/Cu-TCPP(Fe). Cu-TCPP(Fe) nanosheets contribute peroxidase-like activity, and AuNPs have glucose oxidase (GOx) mimicking performance, which induce the cascade catalysis reactions to convert glucose into hydrogen peroxide (H2O2), and then, by using AuNP catalysis, H2O2 oxidizes the no Raman-active leucomalachite green (LMG) into the Raman-active malachite green (MG). Simultaneously, in the presence of AuNPs, sensitive and selective surface-enhanced Raman scattering (SERS) determination of glucose can be achieved. The bioenzyme-free SERS assay based on such AuNPs/Cu-TCPP(Fe) nanosheets is used for detection of glucose in saliva, showing good recovery from 96.9 to 100.8%. The work paves a new way to design a nanozyme-based SERS protocol for biomolecule analysis.
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