炎症体
信号转导衔接蛋白
促炎细胞因子
细胞生物学
半胱氨酸蛋白酶
细胞质
化学
磷酸化
分泌物
半胱氨酸蛋白酶1
目标2
程序性细胞死亡
细胞凋亡
受体
生物
炎症
生物化学
免疫学
作者
Rendong Fang,Rui Wu,Yanna Shen
出处
期刊:PubMed
[National Institutes of Health]
日期:2016-09-01
卷期号:56 (9): 1406-14
被引量:3
摘要
Under the effects of a series of microbial infection and endogenous or exogenous stimuli, inflammasomes are assembled as multiple protein complexes in the cytoplasm, which mainly contain pattern recognition receptors (PRRs), apoptosis-associated speck-like protein containing a CARD (ASC), and pro-caspase-1. The inflammasomes are the platform for caspase-1 activation and subsequent proinflammatory cytokines secretion, and caspase-1 dependent cell death as well. As a key adaptor protein, ASC concatenates PRRs and pro-caspase-1 in the cytoplasm. During inflammasome activation, ASC molecules assemble into large molecule dimers, which is called ASC-speck. The formation of ASC-speck is critical for caspase-1 activation, and ASC-speck becomes a target for the therapy and prevention of inflammatory diseases. In this review, advances in molecular mechanism of ASC-speck formation and the regulation systems for ASC-speck are summarized from the aspects of phosphorylation, ubiquitination and iron channels etc. Finally, the research prospects in this field are discussed.
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