地高辛
心房扑动
药理学
医学
药效学
心房颤动
药代动力学
心力衰竭
心苷
治疗窗口
药品
临床药理学
治疗指标
心脏病学
化学
哇巴因
钠
有机化学
作者
Jiří Patočka,Eugenie Nepovimová,Wenda Wu,Kamil Kuča
标识
DOI:10.1016/j.etap.2020.103400
摘要
Digoxin is a cardiac glycoside used as drug in case of heart problems, including congestive heart failure, atrial fibrillation or flutter, and certain cardiac arrhythmias. It has a very narrow therapeutic window of the medication. Digoxin is toxic substance with well known cardiotoxic effect. In this work, pharmacology and toxicology of digoxin are summarized; Its pharmacokinetics, pharmacodynamics, available acute toxicity data (different species, different administration routes) are summarized in this article. Moreover, its treatment side effect and human poisonings are thoroughly discussed. Finally, appropriate therapy regimen is proposed.
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