生物利用度
紫檀
保健品
胶束
肠细胞
化学
碳酸钙-2
食品科学
橄榄油
小肠
白藜芦醇
生物化学
药理学
细胞
有机化学
医学
水溶液
作者
Yue Sun,Zi-Yuan Xia,Jinkai Zheng,Peiju Qiu,Lijuan Zhang,David Julian McClements
标识
DOI:10.1016/j.jff.2014.12.030
摘要
Nanoemulsion-based delivery systems can be utilized in functional foods and beverages to improve the bioavailability of nutraceuticals. We determined the influence of carrier oil type on the bioavailability of pterostilbene encapsulated in nanoemulsions containing either flaxseed or olive oil as the carrier oil. The nanoemulsions were then subjected to a simulated gastrointestinal tract (mouth, stomach, small intestine), and the resulting micelle phases were used to establish pterostilbene bioavailability using a Caco-2 cell model. Both nanoemulsions significantly enhanced the bioaccessibility of pterostilbene within the micelle phase. However, olive oil nanoemulsions increased trans-enterocyte transport of pterostilbene more effectively than flaxseed oil ones. Moreover, the patterns of metabolism of pterostilbene during its trans-enterocyte transport were dramatically different when pterostilbene was delivered using nanoemulsions with different carrier oil types.
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