磺胺嘧啶银
医学
脂质体
耐受性
泊洛沙姆
伤口愈合
自愈水凝胶
烧伤
外科
皮肤病科
药理学
复合材料
材料科学
纳米技术
不利影响
高分子化学
聚合物
共聚物
作者
H.-H. Homann,Oliver Rosbach,Wiebke Moll,Peter M. Vogt,Guenter Germann,Michael Hopp,Birgit Langer-Brauburger,Karen Reimer,Hans-Ulrich Steinau
出处
期刊:Annals of Plastic Surgery
[Ovid Technologies (Wolters Kluwer)]
日期:2007-10-01
卷期号:59 (4): 423-427
被引量:46
标识
DOI:10.1097/sap.0b013e3180326fcf
摘要
Local treatment of burn injuries with conventional anti-infective preparations does not provide the moist environment that promotes fast wound healing. In a randomized controlled trial the effects of liposome polyvinyl-pyrrolidone-iodine (PVP-I) hydrogel, a novel formulation of PVP-I in a liposome hydrogel with high water-binding capacity, were investigated in 43 patients with partial-thickness burn wounds in an intraindividual comparison with a conventional silver-sulfadiazine cream. Treatment with liposome PVP-I hydrogel resulted in significantly faster complete healing of the burn wounds compared with silver-sulfadiazine cream (9.9 +/- 4.5 days versus 11.3 +/- 4.9; P < 0.015). The cosmetic result (smoothness, elasticity, appearance) was rated as excellent for 37.0% of study wounds with liposome PVP-I hydrogel compared with 13.0% of wounds treated with silver-sulfadiazine cream. Local tolerability was good; handling and change of dressing were rated as easy. Local treatment with liposome PVP-I hydrogel thus provides fast wound healing with a favorable cosmetic result.
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