姜黄素
结合
肽
化学
淀粉样蛋白(真菌学)
抗氧化剂
糖
生物化学
生物物理学
药理学
生物
数学
数学分析
无机化学
作者
Sukanta Dolai,Wei Shi,Christopher Corbo,Chong Sun,Saadyah Averick,Dinali Obeysekera,Mina Farid,Alejandra Alonso,Probal Banerjee,Krishnaswami Raja
摘要
The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-β and tau peptide aggregation is presented. Curcumin inhibits amyloid-β and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Aβ and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more powerful antioxidant.
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