蛋白酶体
细胞生物学
热休克蛋白
细胞内
化学
蛋白质降解
蛋白质折叠
生物化学
蛋白质水解
生物
酶
基因
出处
期刊:Nature
[Springer Nature]
日期:2003-12-01
卷期号:426 (6968): 895-899
被引量:1895
摘要
The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large ATP-dependent proteolytic machine, the 26S proteasome, prevents the accumulation of non-functional, potentially toxic proteins. This process is of particular importance in protecting cells against harsh conditions (for example, heat shock or oxidative stress) and in a variety of diseases (for example, cystic fibrosis and the major neurodegenerative diseases). A full understanding of the pathogenesis of the protein-folding diseases will require greater knowledge of how misfolded proteins are recognized and selectively degraded.
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