肌动蛋白
骨骼肌
旁分泌信号
内分泌学
内科学
自分泌信号
内分泌系统
糖蛋白130
细胞因子
受体
生物
白细胞介素6
激素
医学
作者
Bente Klarlund Pedersen,Mark A. Febbraio
出处
期刊:Physiological Reviews
[American Physiological Society]
日期:2008-10-01
卷期号:88 (4): 1379-1406
被引量:2086
标识
DOI:10.1152/physrev.90100.2007
摘要
Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been suggested that cytokines and other peptides that are produced, expressed, and released by muscle fibers and exert paracrine, autocrine, or endocrine effects should be classified as “myokines.” Recent research demonstrates that skeletal muscles can produce and express cytokines belonging to distinctly different families. However, the first identified and most studied myokine is the gp130 receptor cytokine interleukin-6 (IL-6). IL-6 was discovered as a myokine because of the observation that it increases up to 100-fold in the circulation during physical exercise. Identification of IL-6 production by skeletal muscle during physical activity generated renewed interest in the metabolic role of IL-6 because it created a paradox. On one hand, IL-6 is markedly produced and released in the postexercise period when insulin action is enhanced but, on the other hand, IL-6 has been associated with obesity and reduced insulin action. This review focuses on the myokine IL-6, its regulation by exercise, its signaling pathways in skeletal muscle, and its role in metabolism in both health and disease.
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