妊娠滋养细胞疾病
绒毛膜癌
医学
人绒毛膜促性腺激素
胎盘部位滋养细胞肿瘤
怀孕
疾病
妇科
产科
滋养层肿瘤
妊娠期
胎儿
病理
内科学
胎盘
生物
激素
遗传学
作者
Michael J. Seckl,Neil J. Sebire,Ross S. Berkowitz
出处
期刊:The Lancet
[Elsevier]
日期:2010-08-01
卷期号:376 (9742): 717-729
被引量:747
标识
DOI:10.1016/s0140-6736(10)60280-2
摘要
Summary
Gestational trophoblastic disease encompasses a range of pregnancy-related disorders, consisting of the premalignant disorders of complete and partial hydatidiform mole, and the malignant disorders of invasive mole, choriocarcinoma, and the rare placental-site trophoblastic tumour. These malignant forms are termed gestational trophoblastic tumours or neoplasia. Improvements in management and follow-up protocols mean that overall cure rates can exceed 98% with fertility retention, whereas most women would have died from malignant disease 60 years ago. This success can be explained by the development of effective treatments, the use of human chorionic gonadotropin as a biomarker, and centralisation of care. We summarise strategies for management of gestational trophoblastic disease and address some of the controversies and future research directions.
科研通智能强力驱动
Strongly Powered by AbleSci AI