Analysis of volatile compounds in Herba Asari by single-drop micro-extraction gas chromatography mass spectrometry

A rapid headspace single-drop micro-extraction (mix) gas chromatography mass spectrometry (SDME–GC–MS) for the analysis of the volatile compounds in Herba Asari was developed in this study. A mixed solvent of n-tridecane and butyl acetate (1:1) was finally used for the extraction at 70 °C for 15 min with sample amount of 0.750 g and 100 mesh particle size. Under the determined conditions, the pound samples of Herba Asari were directly applied for the analysis. SDME–GC–MS, SPME–GC–MS and SD–GC–MS methods were compared and the results showed that SDME–GC–MS method was a simple, inexpensive and effective way to measure the volatile compounds in Herba Asari and could be used for the analysis of volatile compounds in complex samples.