急性胰腺炎
细胞因子
医学
免疫系统
胰腺炎
发病机制
免疫学
白细胞介素
炎症
白细胞介素22
内科学
作者
Guanqun Li,Hongze Chen,Liwei Liu,Peng Xiao,Yu Xie,Xinglong Geng,Tao Zhang,Zaixing Yang,Tianqi Lu,Hongtao Tan,Le Li,Bei Sun
标识
DOI:10.3389/fimmu.2021.674803
摘要
Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital role in AP. Specifically, IL-17 has important effects on the immune response and causes interactions between different inflammatory mediators in the AP-related microenvironment. In this literature review, we will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells (especially in acinar cells and immune system cells) in AP pathogenesis. The clinical significance and potential mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP, and we highlight therapeutic strategies that directly or indirectly target IL-17 cytokines in acute pancreatitis.
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