Association of hepatic and systemic inflammation with localized stage II/III periodontitis in young males: The CHIEF oral health study

Abstract Aim To clarify the association between systemic and hepatic inflammation and localized periodontitis which has been reported to vary among races. Materials and Methods The study included 1112 military males, aged 18–40 years, in Taiwan. Participants were classified as periodontally healthy/stage I ( n = 796) or stage II/III periodontitis ( n = 316), according to the 2017 world workshop criteria. Systemic and hepatic inflammation were defined by the highest tertiles of blood leukocyte counts (7.51 × 10 3 /μl) and alanine aminotransferase (30 U/L), respectively. Multiple logistic regression analysis with adjustments for age, metabolic syndrome, betel nut consumption and smoking was carried out. Results There was a significant association between high systemic inflammation, irrespective of hepatic inflammation severity, and localized stage II/III periodontitis (odds ratio [OR], 1.62 [1.09–2.42] and 1.47 [1.00–2.15], respectively, in the presence of high or no hepatic inflammation. However, no significant association was found among participants with low systemic inflammation, irrespective of the severity of hepatic inflammation (OR, 1.31 [0.91–1.91]). Conclusions An association between hepatic inflammation and localized periodontitis in Taiwanese was observed only if systemic inflammation coexisted, possibly accounting for the reported differences in the association between Japanese and non‐Asian populations in prior studies.