化学
烷基
卤化物
三氟甲基
组合化学
光催化
表面改性
氟
卤化
光化学
有机化学
催化作用
物理化学
作者
Pengbo Zhang,Wenwu Li,Weilong Qu,Zhigang Shu,Yingjun Tao,Jin‐Ming Lin,Xia Gao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-11-15
卷期号:23 (23): 9267-9272
被引量:20
标识
DOI:10.1021/acs.orglett.1c03608
摘要
A photoredox and copper-catalyzed fluoroalkylphosphorothiolation of activated and unactivated alkenes via a radical relay mechanism is reported. By employing fluoroalkyl halides as radical precursors and P(O)SH or P(S)SH compounds as coupling partners, a wide range of β-monofluoroalkyl-, -difluoroalkyl-, -trifluoromethyl-, or -perfluoroalkyl-substituted S-alkyl phosphorothioates and phosphorodithioates can be easily constructed under mild conditions with good functional group tolerance. Furthermore, this modular reaction system can be successfully applied to late-stage functionalization of bioactive molecules.
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