CD14型
免疫学
CD16
医学
病理生理学
流式细胞术
新生儿Fc受体
单核细胞
先天免疫系统
抗体
先天性淋巴细胞
髓样
免疫系统
免疫球蛋白G
CD8型
内科学
CD3型
作者
Yanis Ramdani,Cécile Bergua,Christelle Barbet,F. Maillot,A. Bigot,Pauline Beurier,Nicole Ferreira-Maldent,Élisabeth Diot,Valérie Gouilleux‐Gruart
出处
期刊:Lupus
[SAGE Publishing]
日期:2021-10-01
卷期号:30 (12): 1938-1945
被引量:4
标识
DOI:10.1177/09612033211045049
摘要
The neonatal Fc receptor (FcRn) is a ubiquitously expressed protein historically involved in IgG and albumin recycling. Recent data suggest an involvement in the pathophysiology of antibody-mediated autoimmune diseases. Among them, systemic lupus erythematosus (SLE) implies clinical and biological abnormalities of innate and adaptive circulating immune cells, potentially involving newly described functions of FcRn. In this study, FcRn expression was assessed by flow cytometry in peripheral blood leukocytes of 41 SLE patients with either active or inactive disease and 32 healthy donors. FcRn expression in B cells, natural killer cells, and T cells of SLE patients was statistically lower as compared to healthy donors. Conversely, FcRn level was statistically higher in non-classical monocyte subpopulations (CD14+CD16+ monocytes) of SLE patients versus healthy donors providing an interesting perspective to further explore its role in SLE pathophysiology.
科研通智能强力驱动
Strongly Powered by AbleSci AI