生物
寄主(生物学)
组蛋白
生物化学
计算生物学
基因
遗传学
作者
Ara Koh,Filipe De Vadder,Petia Kovatcheva‐Datchary,Fredrik Bäckhed
出处
期刊:Cell
[Elsevier]
日期:2016-06-01
卷期号:165 (6): 1332-1345
被引量:3940
标识
DOI:10.1016/j.cell.2016.05.041
摘要
A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.
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