Research progress of epothilone B,D and their derivatives

Epothilones are natural macrolides targeting microtubule.The epothilones which have been or are being developed are aza-epothilone B,epothilone D,epothilone B,epothilone F,epothilone A.Aza-epothilone D has high potential to become an effective candidate of antitumor agent.From the structure and mechanism,this review summarizes the research progress of epothilone B,D and their derivatives.