再生(生物学)
多细胞生物
神经科学
生物
周围神经
解剖
桥(图论)
外围设备
细胞生物学
细胞
医学
遗传学
内科学
作者
Anne-Laure Cattin,Alison C. Lloyd
标识
DOI:10.1016/j.conb.2016.04.005
摘要
Peripheral nerves show a remarkable ability to regenerate following a transection injury. Downstream of the cut, the axons degenerate and so to regenerate the nerve, the severed axons need to regrow back to their targets and regain function. This requires the axons to navigate through two different environments. (1) The bridge of new tissue that forms between the two nerve stumps and (2) the distal stump of the nerve that remains associated with the target tissues. This involves distinct, complex multicellular responses that guide and sustain axonal regrowth. These processes have important implications for our understanding of the regeneration of an adult tissue and have parallels to aspects of tumour formation and spread.
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