Research of Regulatory B Cell and Multiple Sclerosis

Regulatory B cells( Bregs) mainly come from marginal zone B cells and B1 cells,and inflammatory microenvironment is required for its differentiation/activation. Bregs are capable to performing regulatory functions by production of inhibitory cytokines,such as interleukin-10( IL-10),transforming growth factor-β 1( TGF-β 1),or by interaction with other immune cells. In experimental autoimmune encephalomyelitis( EAE)/multiple sclerosis( MS),Bregs can prior to inhibit the disease's occurrence and reduce the severity by producting IL-10 and inhibiting Th1/Th17.