[Combined effect of synbiotic "Bifistim" and balneologic procedures in patients with osteoarthrosis].

AIM: To study colon microbiota in patients with osteoarthrosis (OA) and its changes after complex treatment with balneologic procedures and inclusion of symbiotic "Bifistim". MATERIALS AND METHODS: Objects of clinico-laboratory study were 689 patients admitted for healthresort therapy in "Yangan-Tau" sanatorium with OA of different severity. Control group consists of 517 patients cured by standard balneologic procedures, 172 patients from comparison group additionally received symbiotic "Bifistim". Microbiological study of stool samples of patients with OA was performed in sanatorium's laboratory before and after treatment course. Feces microbiota was determined with routine methods. RESULTS: Microbiological study of stool samples demonstrated that in 94.6% of patients with OA colon dysbiosis, mostly level I or II, was registered. Severity of colon dysbiotic disturbances and intensity of clinical signs of OA were interrelated. CONCLUSION: Marked dysbiotic changes in colon microbiota were noted in patients with OA and it is recommended to include probiotic preparations in basic course of treatment.