Bioinspired polymeric materials: Progress from molecular science to medical devices

Event Abstract Back to Event Bioinspired polymeric materials: Progress from molecular science to medical devices Kazuhiko Ishihara1 1 the University of Tokyo, Department of Materials Engineering, Japan A cell membrane is mainly composed of phospholipids, membrane proteins, and polysaccharides bound to lipids and proteins. The well-known “fluid-mosaic model,” first proposed by Singer and Nicolson (Fig. 1), has been used to explain the structure of the cell membrane. According to this model, amphiphilic phospholipid molecules are arranged in a bilayer structure and the membrane proteins are positioned in or upon it. The neutral, zwitterionic phosphorylcholine (PC) group bearing phospholipids such as phosphatidylcholines are located in the outer layer of the cell membrane, whereas negatively charged phospholipid molecules such as phosphatidylserines are predominantly found on the inner, cytoplasmic side of the membrane. The PC groups immobilized surface provides an inert surface for biological components including proteins, glycoproteins, and cells. This fact provides particularly significant information for the development of polymer biomaterials. Thus, the phospholipid polymers bearing the PC group provide a significant interest in polymer science, biomaterials science, and biomedical engineering. Much research has been carried out on the synthesis of vinyl monomers bearing phospholipid polar groups. Among these, synthesized monomers-bearing PC groups have strong potential for biomedical applications. The most successful example for this purpose is 2- methacryloyloxyethyl phosphorylcholine (MPC) (Fig. 1). This methacrylate bearing PC group provides various kinds of polymers to the biomedical fields. In 1987, Ishihara and co-workers determined an excellent synthetic route and the purification method for MPC and reported it in 1990[1]. By this procedure, a sufficient amount of MPC can be obtained as a white powder (Fig. 2). The procedure has been improved much more and transferred to the Japanese chemical company, NOF Co. Ltd., and the MPC has been synthesized on an industrial scale since 1999 (Fig. 2). An abundance of research on surface modification with MPC polymers has been carried out due to the versatility and excellent biocompatibility of these systems, and some MPC polymers have already been utilized as surface-modified materials in medical devices (Fig. 2). A biocompatible surface could be obtained via conventional materials, even through a simple coating method[2]. The physical adsorption of MPC polymers to a material surface requires there to be a hydrophobic unit in the polymer chain due to the superhydrophilicity of the MPC unit. Recent progress of the polymer science, well-defined MPC polymer can be synthesized and applied them as a surface modifier of the medical devices, such as artificial hip joint to obtain good lubrication and prevent wear of the materials. References:[1] K.Ishihara, T. Ueda, N. Nakabayashi, Polym J (1990) 355.[2] K. Ishihara and K. Fukazawa, Phosphorus-Based Polymers: From Synthesis to Applications (S. Monge and G. David, Eds) RSC publishing 2014, p68. Keywords: Biocompatibility, Surface modification, Polymeric material, medical application Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Plenary Topic: Surface and interfacial characterization Citation: Ishihara K (2016). Bioinspired polymeric materials: Progress from molecular science to medical devices. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.00252 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kazuhiko Ishihara Google Kazuhiko Ishihara Google Scholar Kazuhiko Ishihara PubMed Kazuhiko Ishihara Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.