结肠炎
樱乳杆菌
免疫系统
炎症
乳酸菌
TLR4型
化学
益生菌
免疫学
促炎细胞因子
医学
生物
细菌
生物化学
发酵
遗传学
作者
Seung-Hwan Seo,Ji‐Sun Shin,Wooseok Lee,Young Kyoung Rhee,Chang‐Won Cho,Hee‐Do Hong,Kyung‐Tae Lee
标识
DOI:10.1016/j.jff.2016.12.045
摘要
Lactobacillus strains are used in the functional food industry as promising probiotics with purported beneficial effects. We recently reported on the immunostimulatory effects of Lactobacillus sakei K040706 (K040706) in macrophages and in a cyclophosphamide-induced immunosuppression model. And this study assessed the anti-inflammatory effects and molecular mechanisms involving K040706 in a mouse model of colitis with dextran sodium sulfate (DSS). K040706 significantly attenuated the clinical signs and histological characteristics in DSS-induced colitic mice, which are well-correlated with the restoration of tight junction protein expression and the significant reduction of immune cell infiltration and expression of ICAM-1 and VCAM-1. Moreover, K040706 reduced the abnormal expression of pro-inflammatory mediators, such as iNOS, TNF-α, IL-1β, and IL-6, and the activation of NF-κB, STAT3 and TLR4. K040706 also improved the composition of intestinal microbiota. These results suggest K040706 has shown significant anti-inflammatory effects in a DSS-induced colitis model and has the potential to treat IBD.
科研通智能强力驱动
Strongly Powered by AbleSci AI