Acyclic Isoprenoids of Endophytic Aspergillus sp. Y-12 from Panax notoginseng

Background: Panax notoginseng, a traditional Chinese materia medica, is widely used in Chinese medicine to arrest internal and external hemorrhages, eliminate blood stasis, improve blood circulation, disperse bruises, and reduce swelling and pain. However, root rot hampers the sustainable development of planting for P. notoginseng. Root rot always occurs in the presence of pathogenic microbes. Endophytic microorganisms, residing in the living tissues of the host plant and forming complex relationships with the host, are found in every plant on the earth. The chemical investigation focused on Aspergillus has led to the diverse classes of active compounds. This research was a part of our ongoing search for naturally occurring anti-phytopathogen products from endophytic fungi associated with P. notoginseng. Keywords: Aspergillus sp., acyclic isoprenoid, anti-phytopathogenic activity, endophyte, Panax notoginseng, structural elucidation.