Solvent-controlled divergent 1,2-dialkylation and 1,1,2-bromodialkylation of terminal alkynes to access difluoroalkylated cyclopentanes

We have developed a mild and efficient photocatalytic strategy that enables both 1,2-difunctionalization and 1,1,2-trifunctionalization of terminal alkynes with bromodifluoroacetates, simply by switching the reaction solvent.