Photothermal–Immunomodulatory Hydrogel Reinforced by Ti 3 C 2 /ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

and ZnAl-LDH (TiZ) nanosheets and infused with chlorogenic acid, forming CTiZ. These were cloaked in membranes derived from apoptotic neutrophils to create a NETs-mimetic functional bacterial trapper (CTiZM), which was then encapsulated within a thermoresponsive dopa-poly(N-isopropylacrylamide) hydrogel (dopa-PNIPAm, DP), yielding a composite hydrogel system designated CTiZM@DP. This sophisticated platform amplifies antibacterial potency through effective microbial entrapment and the generation of reactive oxygen species, while simultaneously orchestrating the polarization of macrophages toward a reparative M2 phenotype under the influence of gentle photothermal stimulation. Collectively, this integrative strategy heralds a promising therapeutic modality for the eradication of multidrug-resistant infections and the enhancement of wound healing in individuals with diabetes.