合成生物学
生物
计算生物学
酵母
寄主(生物学)
生物技术
遗传学
作者
Sonja Billerbeck,Roy Walker,Isak S. Pretorius
标识
DOI:10.1016/j.tibtech.2024.03.003
摘要
Killer yeasts secrete protein toxins that are selectively lethal to other yeast and filamentous fungi. These exhibit exceptional genetic and functional diversity, and have several biotechnological applications. However, despite decades of research, several limitations hinder their widespread adoption. In this perspective we contend that technical advances in synthetic biology present an unprecedented opportunity to unlock the full potential of yeast killer systems across a spectrum of applications. By leveraging these new technologies, engineered killer toxins may emerge as a pivotal new tool to address antifungal resistance and food security. Finally, we speculate on the biotechnological potential of re-engineering host double-stranded (ds) RNA mycoviruses, from which many toxins derive, as a safe and noninfectious system to produce designer RNA.
科研通智能强力驱动
Strongly Powered by AbleSci AI