Catalytic α-C–H functionalization of carbonyl compounds via SET-induced formation of α-carbonyl radicals

The catalytic α-functionalization of carbonyl compounds via SET induced formation of α-carbonyl radicals compares favorably with traditional electrophilic functionalization of enolates. The present review article showcases recent progress in the catalytic functionalization of ketones and carboxylic acid equivalents via single electron transfer (SET) induced formation of α-carbonyl radicals. Transition metal catalysed and photoredox-catalysed SET induced transformations of α-carbonyl radicals are primarily featured here.