AI‐Guided Design of Antimicrobial Peptide Hydrogels for Precise Treatment of Drug‐resistant Bacterial Infections

/SH coordination to produce an AI-AMP-hydrogel. In vitro, the AI-AMP-hydrogel exhibits > 99.99% bactericidal efficacy against Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). Furthermore, Cu-BTO converts mechanical stimulation into electrical signals, thereby promoting the expression of growth factors and angiogenesis. In a rat model with dynamic wounds, the AI-AMP hydrogel significantly reduces the MRSA load and markedly accelerates wound healing. Therefore, the AI-guided biomaterial development strategy offers an innovative solution to precisely treat drug-resistant bacterial infections.