Poly(Oligo(Ethylene Glycol) Methacrylate)-Based Polymers in Biomedical Applications: Preparation and Applications

While poly(ethylene glycol) (PEG) has been widely applied in a host of biomedical applications due to its antifouling properties, its limited potential for functionalization and emerging concerns over potential immunogenicity have inspired the development of PEG alternatives. Herein, we review the use of poly(oligo(ethylene glycol) methacrylate) (POEGMA) as a PEG alternative that can provide significantly more synthetic versatility, minimize immunogenicity, and open up additional applications (e.g., thermoresponsive devices) based on precise control over the (co)polymer composition, the backbone molecular weight, and the side chain molecular weight. The synthetic pathways and applications of POEGMA as a surface or biomolecular grafting agent, a hydrogel, a microgel/nanogel, and a nanoparticle stabilizer are comprehensively summarized, with applications in drug delivery, tissue engineering/wound healing, and biosensing particularly highlighted to show how the unique properties of POEGMA can impart improved or unique application performance. Future directions to better leverage the properties of POEGMA in diverse applications are also proposed.